Tag: Cystic Fibrosis

  • The Quiet Miracles of AI

    The Quiet Miracles of AI

    The Quiet Miracles of AI

    “Technology is a useful servant but a dangerous master.”
    — Christian Lous Lange

    This week’s Cryptogeddon Briefing is a little different.

    Normally, this space is where I explore the technologies, cyber threats, geopolitical shifts, and emerging ideas that inspire my writing—and, ultimately, the world of Cryptogeddon. Most weeks, that means discussing artificial intelligence in the context of cybersecurity, autonomous systems, espionage, or the changing balance of power between nations.

    This week, though, I found myself thinking about AI from a very different perspective.

    The idea came after a conversation over dinner.

    The topic of artificial intelligence came up, and as it so often does these days, opinions around the table were mixed. Some people were optimistic. Others were skeptical. The concerns were familiar: AI-generated artwork replacing artists, copyright, deepfakes, misinformation, job displacement, and the growing uncertainty surrounding where this technology is taking us.

    They’re fair concerns.

    In fact, they’re concerns I share.

    Like every transformative technology before it, artificial intelligence will undoubtedly be used for both good and bad. It will create incredible opportunities while introducing entirely new risks. Pretending otherwise would be naïve.

    But as I listened to the discussion, I couldn’t help thinking about another side of AI—one that rarely dominates headlines or social media debates.

    It reminded me that while we spend enormous amounts of time asking what AI might take away from us, we spend surprisingly little time asking what it might give us.


    That thought brought me to my daughter.

    “The good physician treats the disease; the great physician treats the patient who has the disease.”
    — Sir William Osler

    She has cystic fibrosis.

    If you’ve never known someone with CF, it’s a genetic disease caused by mutations in the CFTR gene. Those mutations disrupt how salt and water move through cells, producing the thick mucus that damages the lungs and digestive system. For decades, treatment focused primarily on managing symptoms: daily physiotherapy, inhaled medications, repeated courses of antibiotics, and frequent hospital stays whenever infections became severe.

    When my daughter was born, there was hope—but there were also countless unanswered questions.

    Researchers had identified the genetic cause of the disease, but understanding exactly how hundreds—and eventually thousands—of different mutations affected the CFTR protein required years of painstaking laboratory research. Every discovery was earned through thousands of experiments, each one consuming time, funding, and the efforts of countless scientists.

    A realistic, documentary-style close-up photograph inside a biomedical research laboratory. Shallow depth of field. Gloved hands holding a pipette carefully dispensing liquid into petri dishes on a stainless steel lab bench. The background is softly blurred laboratory equipment and shelving. Natural, soft white lighting. No dramatic lighting, no glowing screens, no futuristic elements. Clean, subtle, professional, editorial medical photography. Landscape orientation.

    Drug development was no different.

    Researchers would identify promising compounds, synthesize them, test them in the laboratory, modify them, and begin the process again. Most candidates failed. The few that succeeded often required more than a decade of research and billions of dollars before they ever reached patients.

    Thankfully, that work paid off.

    Today, my daughter is nineteen years old. She lives what is, for all practical purposes, a normal life. She still has cystic fibrosis. She still follows a treatment regimen every day. But she’s healthy, active, independent, and planning her future just like any other young adult.

    That’s nothing short of extraordinary.

    And while AI didn’t create those first breakthrough therapies, it’s beginning to change how the next generation of discoveries will happen.


    Artificial intelligence doesn’t replace scientific curiosity—it amplifies it.

    This is where artificial intelligence becomes genuinely exciting—not because it’s generating artwork or writing marketing copy, but because it’s helping scientists ask better questions.

    Modern AI systems can analyze enormous biological datasets in hours rather than months. They can compare thousands of genetic mutations, identify patterns that would be nearly impossible for humans to detect unaided, and predict how specific mutations alter the shape and function of proteins. Instead of relying entirely on trial and error, researchers can now use AI to prioritize the most promising hypotheses before stepping into the laboratory.

    That doesn’t replace science.

    It makes science more efficient.

    One of the most exciting developments has been AI-assisted protein modelling. Understanding exactly how a mutation changes the three-dimensional shape of a protein—and how a potential drug might restore its function—once required years of painstaking structural biology. Today, AI systems such as AlphaFold can generate remarkably accurate structural predictions in hours, allowing researchers to focus precious laboratory time where it’s most likely to produce meaningful results.

    AI is also transforming medical imaging. Researchers are using machine learning to identify subtle changes in CT scans that may indicate disease progression earlier than conventional methods. They’re studying how bacterial populations evolve inside the lungs of people with cystic fibrosis, helping predict antibiotic resistance and personalize treatments. AI is helping researchers identify better candidates for clinical trials, reducing the time required to evaluate promising therapies.

    None of these breakthroughs eliminate the need for scientists.

    They eliminate wasted effort.

    Every experiment that doesn’t need to be performed because AI helped identify a dead end means researchers can spend more time pursuing ideas with genuine potential. Every month saved in research is another month that a promising therapy could reach the people waiting for it.

    And while cystic fibrosis is one example, the same technologies are now accelerating research into cancer, Alzheimer’s disease, rare genetic disorders, antibiotic discovery, and countless other medical challenges.

    That’s a much bigger story than AI-generated artwork.

    And yet, both conversations are about the same technology.


    Technology itself is remarkably neutral.

    Electricity powers hospitals.

    It also powers electric chairs.

    The Internet connects families across continents.

    It also spreads misinformation across them.

    Encryption protects political dissidents.

    It also protects organized crime.

    Artificial intelligence belongs in exactly the same category.

    The same machine learning algorithms helping researchers discover life-saving medicines can also help militaries identify targets faster, guide autonomous drones, improve missile accuracy, or analyze satellite imagery to track troop movements. Those very same technologies can also detect incoming missile attacks, improve battlefield medicine, assist humanitarian rescue operations, strengthen cyber defenses, and protect civilian infrastructure.

    The technology hasn’t changed.

    Only the objective has.

    That’s why I don’t think AI is inherently good or inherently bad.

    I think it’s something much simpler.

    It’s a multiplier.

    Put AI in the hands of a scammer and they’ll scam more people.

    Put it in the hands of a military and they’ll build more capable weapons—or more capable defenses.

    Put it in the hands of an artist and they’ll create in entirely new ways.

    Put it in the hands of a physician or researcher, and they’ll ask bigger questions, analyze more data, and discover answers faster than they could alone.

    AI doesn’t determine the outcome.

    People do.

    The tool simply multiplies whatever intentions we bring to it.


    “The future is already here—it’s just not evenly distributed.”
    — William Gibson

    "The future is already here—it's just not evenly distributed."
— William Gibson

    If you had told me twenty years ago that one day my daughter would wake up, take a handful of pills, complete her treatments, and then go about living what is—for all practical purposes—a normal life, I would have struggled to believe you.

    That future wasn’t built by artificial intelligence alone.

    It was built by thousands of researchers, physicians, engineers, patients, and families who spent decades advancing science one careful step at a time.

    Now, for the first time, many of those same researchers have a tool that allows them to move faster than ever before.

    Artificial intelligence won’t replace human ingenuity.

    It will amplify it.

    And perhaps that’s the conversation we should be having.

    Not whether AI can generate a beautiful painting.

    Not whether it can replace a writer or an illustrator.

    Those are important discussions, and they’re worth having.

    But they aren’t the whole story.

    The quiet miracles of AI won’t be measured by the pictures it generates.

    They’ll be measured by the discoveries it accelerates, the diseases it helps us understand, and ultimately, the lives it helps us save.


    Further Reading

    1. Jumper, J. et al. (2021). Highly accurate protein structure prediction with AlphaFold. Nature, 596, 583–589.
    2. Paul, D. et al. (2021). Artificial Intelligence in Drug Discovery and Development. Drug Discovery Today.
    3. De Marchis, M. et al. (2023). Machine Learning Applications in Cystic Fibrosis: A Narrative Review.
    4. Cystic Fibrosis Foundation. Research and Clinical Trials Pipeline.
    5. Nature Reviews Drug Discovery (2024). Artificial Intelligence and the Future of Biomedical Research.

  • Team Katie – Great Strides 2012 results!

    Team Katie - Great Strides 2012 photo gallery
    Team Katie – Great Strides 2012 photo gallery

    To all Team Katie supporters,

    Thank you so much for your generous contributions to Team Katie in support of the 2012 Great Strides fundraiser. We continue to be overwhelmed by the tremendous outpouring of generosity and encouragement that we’ve received from you, our friends, as we do what we can to help find a cure for Cystic Fibrosis.

    This annual fundraiser has been a huge motivator for us. In many ways, we feel powerless to help Katie. Our fundraising efforts have been one of the key ways that we’ve had to focus our energy in a positive way to help Katie live a long, healthy life. The funds that we raise are efficiently used to support CF patients and to help find a cure.

    Some numbers from today:
    Total money raised for Cystic Fibrosis Canada = $2,082,058+
    Total money raised for the Niagara Great Strides Walk at Safari Niagara = $40,000+
    Total money raised for Team Katie = $19,000+
    Total sponsors for Team Katie = 251
    Total Team Katie walkers today = 65

    You can see a slideshow of some pics from this weekend’s event here:
    http://www.flickr.com/photos/toddhdow/sets/72157629922562944/show/

    And, the complete flickr photo stream of the event is located here:
    http://www.flickr.com/photos/toddhdow/sets/72157629922562944/

    Your monetary contributions have been a huge source of inspiration for us and we thank you for that. Not only are you helping fund the fight to beat CF, but each of you have also given our family a boost – we live with CF on a daily basis. We try not to get down, and most of the time, we’re okay. But, sometimes it all catches up with us. The weight of a fatal disease in the family makes for some grim thoughts from time to time. But, we feel comfort knowing that we have so many friends that support us and rally behind us in this cause.

    To everyone that has helped us this year, we thank you. Each of you, in contributing your time, money, thoughts and prayers are helping to save Katie’s life. And for that, we are eternally grateful.

    Much love,

    Todd, Julie, Noah, Katie & Riley

  • Team Katie – Great Strides 2012

    Katie Dow - Team Katie 2012Folks,

    As many of you know, our daughter Katie has Cystic Fibrosis. Katie was diagnosed with CF on September 30 2008. She was 17 months old at the time.

    On Sunday May 27 2012, Cystic Fibrosis Canada will be hosting the annual Great Strides walk for cystic fibrosis. We will be walking and invite you to join us for this annual event.

    CF, which affects the lungs and the digestive system, is the most common, fatal, genetic disease affecting Canadian children and young adults. Forty years ago, most children with CF did not live long enough to attend kindergarten. Today, half of Canadians with CF are expected to live into their 40s and beyond.

    While life span has improved for patients with CF, quality of life is still an issue. Daily treatments, medication, clinic visits and health challenges are always present. When Katie is healthy, we do two treatment sessions a day with her. When she is sick (cold, flu, etc.), we do three or four treatment sessions each day with her.

    Here’s a brief list of her regular medicine intake and treatment regimen:
    – approx 30 pills a day (enzymes – they help Katie digest food);
    – vitamin supplements;
    – 2 to 4 Pediasure nutrition supplement drinks each day;
    – Nebulizer + medicine – basically, a mist mask that Katie wears twice a day for 20 minutes each time;
    – Percussion treatment – 20 minutes of hitting her chest and back – twice a day;
    – Inhaled antibiotics – she’s been on this medicine pretty much non-stop for the last 6 months;

    Plus, the following “specialty items” when she is sick with a cold, flu or other sickness:
    – Oral antibiotics;
    – Additional medicine in her nebulizer from time to time as her health dictates;
    – Additional nebulizer and percussion treatment – typically 3 or 4 treatment sessions a day when she’s sick;

    Please watch our Great Strides 2012 video, which provides a window into our world:

    Each year, on the last Sunday in May, friends, family and co-workers of people with cystic fibrosis participate in “Great Strides”, which is Cystic Fibrosis Canada’s largest national fundraising event. Walk with us on Sunday May 27 2012.

    To assist, you can:
    1. Donate money;
    2. Donate and/or collect pledges and Walk with us on Sunday May 27; and/or
    3. Recruit others to join us in this fundraising event;

    To join our team, “Team Katie”, and walk with us on May 27 at Safari Niagara in Stevensville, click here: Join Team Katie

    To sponsor us directly in our fundraising efforts for Team Katie, click here: Sponsor Team Katie

    We thank you for your support. Our wish is that one day, CF will stand for “Cure Found”.

    Thanks!

    Todd, Julie, Noah, Katie & Riley Dow

  • Team Katie – Great Strides 2011 results!

    Team Katie - Great Strides 2011
    Team Katie – Great Strides 2011

    To all Team Katie supporters,

    Thank you so much for your generous contributions to Team Katie in support of the 2011 Great Strides fundraiser. We continue to be overwhelmed by the tremendous outpouring of generosity and encouragement that we’ve received from you, our friends, as we do what we can to help find a cure for Cystic Fibrosis.

    This annual fundraiser has been a huge motivator for us. In many ways, we feel powerless to help Katie. Our fundraising efforts have been one of the key ways that we’ve had to focus our energy in a positive way to help Katie live a long, healthy life. The funds that we raise are efficiently used to support CF patients and to help find a cure.

    Some numbers from today:
    Total money raised for the Canadian Cystic Fibrosis Foundation = $1,961,608+
    Total money raised for the Niagara-Hamilton Great Strides Walk = $107,686
    Total money raised for Team Katie = $17,154
    Total sponsors for Team Katie = 243
    Total Team Katie walkers today = 80

    You can see a slideshow of some pics from this weekend’s event here:
    http://www.flickr.com/photos/toddhdow/sets/72157626383527816/show/

    And, the complete flickr photo stream of the event is located here:
    http://www.flickr.com/photos/toddhdow/sets/72157626383527816/

    Your monetary contributions have been a huge source of inspiration for us and we thank you for that. Not only are you helping fund the fight to beat CF, but each of you have also given our family a boost – we live with CF on a daily basis. We try not to get down, and most of the time, we’re okay. But, sometimes it all catches up with us. The weight of a fatal disease in the family makes for some grim thoughts from time to time. But, we feel comfort knowing that we have so many friends that support us and rally behind us in this cause.

    To everyone that has helped us this year, we thank you. Each of you, in contributing your time, money, thoughts and prayers are helping to save Katie’s life. And for that, we are eternally grateful.

    Much love,

    Todd, Julie, Noah, Katie & Riley

  • Breathe Easy Nebulizer Mask Holder

    Breathe Easy Nebulizer Mask Holder
    Breathe Easy Nebulizer Mask Holder

    All CF parents out there, you must check out this product: The Breathe Easy Nebulizer Mask Holder

    What a great device! Julie found this online and ordered one. Order total = $31.50 which includes shipping. The device even came with an extra “Bubbles the Fish Pediatric Aerosol Mask”, which is a bonus so that we can rotate masks more often.

    To use it, all you do is put the strap on your child’s head, adjust the fish mask on the face and then attach the nebulizer to the front of the mask. Easy as 1 2 3.

    The product creator, Melissa, was motivated to make this mask holder for a friend’s child, who has CF. According to Melissa, “This mask holder was created for a friend of mine to help with her son’s breathing treatments. Her little boy has Cystic Fibrosis and must have multiple breathing treatments every day. She struggled with getting the nebulizer mask, with its flimsy elastic strap, to stay on his head securely.”

    And, as an added bonus, Melissa will also donate a portion of any purchase referred by Breathing As A Family to Cystic Fibrosis Canada! Simply mention that you heard about this here (and mention Team Katie) during the checkout process (there is a spot for additional comments on Etsy when you place your order) and Melissa will do the rest.

    Thanks to Melissa (mktdesigns on Etsy) for providing such a great product.

    Please pass this along to any other CF families that you know!

    Todd